Recent findings from a study conducted by experts in the field reveal that exercise not only prevents cancer incidence but also significantly reduces the risk of cancer recurrence. The study sheds light on the underlying mechanisms of this relationship, providing valuable insights into how exercise acts as a powerful shield against cancer progression.

Here's a quick summary of the key points:

Exercise-Induced Metabolic Shield:

The research suggests that exercise induces a metabolic reprogramming of internal organs. This reprogramming increases nutrient demand, creating a protective shield against metastatic colonization by limiting nutrient availability to the tumor. BASICALLY: exercise creates a metabolic environment that makes it challenging for cancer cells to thrive.

Human & Mice Models-Proteomic Analysis:

Proteomic analyses of both murine internal organs and human subjects demonstrate that exercise triggers catabolic processes, glucose uptake, mitochondrial activity, and increased carbohydrate utilization. These changes contribute to the exercise-induced metabolic shield, reinforcing the body's defense against cancer. 

Mice models-Protection Against Metastases:

In mice models and melanoma studies, exercise prior to cancer injection showed significant protection against metastases in distant organs. This protection was found to be dependent on mTOR activity, and inhibiting the mTOR pathway reversed the exercise-induced metabolic shield.

Human models- Real-World Impact:

A 20-year prospective study involving a large human cohort revealed that exercise becomes significantly pronounced in highly metastatic cancer, highlighting the preventive power of exercise. BASICALLY: More exercise reduces your risk of mets in cancer and this was proven in humans over 20 years! 

Potential Strategy for Prevention:

The research suggests that exercise-induced high nutrient demand in internal organs represents a potential strategy to prevent metastasis. By reducing nutrient availability to tumor cells, exercise offers a unique opportunity to block metastasis and challenge the metabolic needs of cancer cells.

I hope this information empowers you to continue making positive choices for your health. As healthcare professionals, your well-being is essential, and we believe that staying active can play a crucial role in maintaining a healthy and resilient body.

If you have any questions or would like more details, feel free to reach out. Here's to a healthier and stronger you!